H111-H7 is a WW domain containing E3 ubiquitin 27 protein ligase 2 (WWP2) inhibitor with a KD of 717 nM. H111-H7 inhibits WWP2 expression, restores the succinate dehydrogenase complex subunit C (SDHC) level, and defers the acute kidney injury (AKI)-to-chronic kidney disease (CKD) transition in unilateral kidney ischemia-reperfusion (UIR) mice. H111-H7 can be used for AKI-to-CKD transition research[1].
Molecular Weight:
327.81
CAS Number:
[220965-54-8]
Formula:
C13H10ClNO3S2
Target:
E1/E2/E3 Enzyme
Application Notes:
MCE Product type: Reference compound
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