NSS-18 is a potent and reversible inhibitor of AChE and MAO-B, with IC50 values of 1.53 and 1.51 µM respectively. NSS-18 can inhibit the self-aggregation of Abeta. NSS-18 inhibits the intracellular generation of ROS induced by Abeta. NSS-18 shows a moderate neuroprotective effect against 6-OHDA (HY-B1081)-induced neurotoxicity. NSS-18 can form chelates with metal ions such as Cu, Fe, and Zn, with the strongest chelation being with Cu. NSS-18 can be used for the study of Alzheimers disease[1].
Molecular Weight:
405.44
Formula:
C24H23NO5
Target:
Amyloid-beta,Cholinesterase (ChE),Monoamine Oxidase,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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