CDK8-IN-20 (Compound 67j) is a selective, potent and orally active type I CDK8 inhibitor with an IC50 of 70.5 nM. CDK8-IN-20 shows IC50 values of 147.8, 726.9 and 217.4 nM for homologous kinase CDK19, CDK7 and CDK9. CDK8-IN-20 can inhibit the Wnt/beta-catenin pathway and downregulate the expression of beta-catenin, Cyclin D1, and c-Myc. CDK8-IN-20 can induce ROS production and cause G2/M and S phase arrest. CDK8-IN-20can be used for the research of cancer, such as colon cancer[1].
Molecular Weight:
469.51
Formula:
C22H23N5O5S
Target:
CDK,c-Myc,Reactive Oxygen Species (ROS),Wnt,beta-catenin
Application Notes:
MCE Product type: Reference compound
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