INVA8001 (ASB17061) is a highly selective and orally active chymase inhibitor with IC50 values for human chymase and mouse mast cell proteinase 4 (mMCP-4) of 0.02 and 0.03 µM, respectively. INVA8001 exhibits IC50 values for bovine alpha-chymotrypsin and human cathesin G of 3.4 and 32.1 µM, respectively, and it shows over 1000-fold selectivity for other related serine proteases. INVA8001 inhibits mast cells in a mouse primary sclerosing cholangitis (PSC) model, improves bile duct pathology, and alleviates bile stasis, demonstrating anti-inflammatory and anti-fibrotic effects[1].
Molecular Weight:
620.09
CAS Number:
[1312993-34-2]
Formula:
C29H38ClN5O8
Target:
Proteasome
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
