Microtubule-IN-14 (Compound 10u) is a microtubule inhibitor. Microtubule-IN-14 inhibits the polymerization of tubulin, thereby preventing the formation of the spindle apparatus in cell mitosis and blocking the cell cycle at the G2/M phase. Microtubule-IN-14 induces a decrease in mitochondrial membrane potential and a burst of reactive oxygen species (ROS), promoting tumor cell apoptosis. Microtubule-IN-14 can be used for the study of non-small cell lung cancer and liver cancer[1].
Molecular Weight:
460.45
Formula:
C26H21FN2O5
Target:
Apoptosis,Microtubule/Tubulin,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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