EGFR/BRAFV600E-IN-6 (Compound 7c) is a dual EGFR/BRAFV600E inhibitor with IC50 values of 0.12 and 0.05 µM. EGFR/BRAFV600E-IN-6 can activate caspase-3/8/9, unregulate Bax expression and downregulate Bcl-2 levels. EGFR/BRAFV600E-IN-6 can induce apoptosis and shows antioxidant activity. EGFR/BRAFV600E-IN-6 can be used for the research of cancer, such as colon cancer[1].
Molecular Weight:
507.56
Formula:
C28H21N5O3S
Target:
Apoptosis,Bcl-2 Family,Caspase,EGFR,Raf
Application Notes:
MCE Product type: Reference compound
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