CDK2-IN-51 is a pyrazolopyridine derivative, a CDK2 inhibitor with an IC50 of 23.47 nM. CDK2-IN-51 does not have a pro-apoptotic effect and had no significant effect on CDK2 protein expression. CDK2-IN-51 reduces expression of DNA replication factors (Polalpha, MCM7, ORC2, and ORC4) and pre-G1 cell cycle arrest. CDK2-IN-51 can be used for the research of colorectal cancer[1].
Molecular Weight:
288.35
CAS Number:
[1443-10-3]
Formula:
C18H16N4
Target:
CDK
Application Notes:
MCE Product type: Reference compound
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