019854-B06 is a potent inhibitor of Tat-mediated HIV-1 transcription (IC50 = 1.44 µM), exhibiting antiviral activity against HIV-1 (EC50 = 0.83 µM). 019854-B06 binds to Tat peptide (KD = 33.5 µM), but not to TAR RNA. 019854-B06 neither promotes Tat degradation nor disrupts the Tat/CycT1 complex, supporting a Tat-centric, nondegradative mechanism[1].
Molecular Weight:
454.60
Formula:
C28H38O5
Target:
HIV
Application Notes:
MCE Product type: Reference compound
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