GK730 is a potent and selective SARS-CoV-2 main protease inhibitor with an IC50 of 5.75 nM. GK730 does not inhibit cathepsin B, while exhibits weak inhibition of cathepsin L (IC50 = 11 µM). GK730 can simultaneously block the replication of the virus and the entry pathways for variants such as Omicron into cells. GK730 demonstrates an EC50 value of 5.70 µM against a wild-type SARS-CoV-2 strain in Vero E6 cells and CC50 value greater than 100 µM. GK730 can be used for the research of COVID-19[1].
Molecular Weight:
643.75
Formula:
C31H41N5O8S
Target:
SARS-CoV
Application Notes:
MCE Product type: Reference compound
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