Anti-Influenza agent 10 (Compound 41) is an influenza A virus RNA-dependent RNA polymerase (RdRp) inhibitor. Anti-Influenza agent 10 exhibits potent antiviral activity against A/PR/8/34(H1N1) with an IC50 of 0.29µM and a KD of 4.11 µM. Anti-Influenza agent 10 can inhibit the assembly of the viral RdRp complex by disrupting the protein interaction between PA and PB1 subunits, thereby blocking the transcription and replication of the viral genome. Anti-Influenza agent 10 shows significant broad-spectrum effects on multiple influenza virus strains, such as H3N2, H3N8 and H9N2 with IC50 values of 3.96, 1.91 and 1.45 µM. Anti-Influenza agent 10 can be used for the research of influenza A Virus Infection[1].
Molecular Weight:
478.99
Formula:
C25H23ClN4O2S
Target:
DNA/RNA Synthesis,Influenza Virus
Application Notes:
MCE Product type: Reference compound1
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