NEPP11 is a cyclopentenone prostaglandin analogue. NEPP11 can inhibit glutamate-induced HT22 cell death in mouse hippocampus and prevent manganese-induced apoptosis in PC12 cells. NEPP11 can activate Nrf2 and maintain MEK1/2 and ERK1/2 activity by inhibiting c-Raf downregulation. NEPP11 exerts a neuroprotective effect in a mouse model of focal cerebral ischemia caused by permanent middle cerebral artery occlusion[1].
Molecular Weight:
396.57
CAS Number:
[313051-12-6]
Formula:
C26H36O3
Target:
Apoptosis,Drug Derivative,ERK,Keap1-Nrf2,MEK,Raf
Application Notes:
MCE Product type: Reference compound
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