KFP-H008 is an orally active potassium-competitive acid blocker. KFP-H008 inhibits gastric acid secretion through blocking H+-K+-ATPase. KFP-H008 reduces ethanol-induced gastric ulcer index and malonaldehyde as well as proinflammatory cytokine expression in vivo. KFP-H008 downregulates p-p38 MAPK and p65 NF-kappaB expression. KFP-H008 blocks histamine-stimulated acid secretion in rat and dog models. KFP-H008 can be studied in research on acid-related disease, such as ethanol-induced gastric ulcer and gastric epithelial cell damage[1][2][3].
Molecular Weight:
366.44
CAS Number:
[1876453-55-2]
Formula:
C19H18N4O2S
Target:
ATP Synthase,p38 MAPK
Application Notes:
MCE Product type: Reference compound
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