TAC 363 is a selective tachykinin NK-2 receptor antagonist. TAC 363 shows a rightward shift in the contractile response curve induced by Neurokinin A (HY-P0197) with a pA2 of 9.82. TAC 363 has a weak antagonistic effect on NK-1 receptors. TAC 363 can inhibit Neurokinin A-induced bronchoconstriction in guinea pigs with an ED50 of 0.3 mg/kg. TAC 363 can be used for the research of bronchial asthma[1].
Molecular Weight:
712.84
CAS Number:
[172081-08-2]
Formula:
C38H48N8O6
Target:
Neurokinin Receptor
Application Notes:
MCE Product type: Reference compound
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