ZW-6-052 (compound 20), the derivative of ZW-18-116 (HY-180550), is a dual-target PROTAC degrader for the oncoproteins TRKA and RET. ZW-6-052 induces degradation of TMP3-TRKA in KM12 mouse xenograft models. ZW-6-052 can be used for RET or TRKA-derived cancer research, such as thyroid, lung, and colon cancers[1].
Molecular Weight:
871.94
Formula:
C46H49N9O9
Target:
PROTACs,RET,Trk Receptor
Application Notes:
MCE Product type: Reference compound
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