PF-915275 (Standard) is the analytical standard of PF-915275. This product is intended for research and analytical applications. PF-915275 is a potent, selective and orally active human 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) inhibitor with a Ki of 2.3 nM and an EC50 of 15 nM (in HEK293 cells). The dose-dependent effect of PF-915275 on conversion of cortisone to cortisol in primary human and monkey hepatocytes, with an EC50 of 20 and 100 nM, respectively[1][2][3].
Molecular Weight:
350.39
CAS Number:
[857290-04-1]
Formula:
C18H14N4O2S
Target:
11beta-HSD,Reference Standards
Application Notes:
MCE Product type: Reference Standards
* VAT and and shipping costs not included. Errors and price changes excepted
