LUF7996 is a CCR2 PROTAC Degrader degrading CCR2 with DC50 = 2.6 µM. LUF7996 demonstrates engagement of both and the E3 ligase cereblon and displays sustain and concentration-dependent degradation of CCR2. LUF7996 reliance on the lysosomal pathway to induce CCR2 degradation. LUF7996 efficiently inhibits monocyte migration in virto[1].
Molecular Weight:
860.68
CAS Number:
[3104736-80-0]
Formula:
C39H34Cl2F3N5O8S
Target:
CCR,PROTACs
Application Notes:
MCE Product type: Reference compound
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