LOXL2/sGC modulator-1 (Compound 11k) is a LOXL2 inhibitor (IC50 = 0.13 µM) and an sGC activator. LOXL2/sGC modulator-1 shows good selectivity for LOX (IC50 > 45.9 µM) and LOXL3 (IC50 = 1.30 µM). LOXL2/sGC modulator-1 significantly increases intracellular cGMP levels in the presence of the gGC inhibitor ODQ (HY-101255). LOXL2/sGC modulator-1 significantly inhibits hypoxia-induced collagen deposition and cross-linking, while promoting vasodilation. LOXL2/sGC modulator-1 can be used for the study of pulmonary arterial hypertension[1].
Molecular Weight:
459.42
Formula:
C23H20F3N3O4
Target:
Guanylate Cyclase,Monoamine Oxidase
Application Notes:
MCE Product type: Reference compound
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