GRK5-IN-5 (Compound 4a) is a selective G protein-coupled receptor (GPCR) kinase 5 (GRK5) inhibitor with an IC50 of 0.03 µM. GRK5-IN-5 shows IC50 values of 2.2 and 0.036 µM for GRK2 and GRK6. GRK5-IN-5 has potent anti-myocardial hypertrophy activity and also inhibits the proliferation of non-myocardial cells. GRK5-IN-5 can inhibit the abnormal upregulation of hypertrophy marker genes Nppa and Nppb, thus blocking pathological myocardial remodeling. GRK5-IN-5 can be used for the research of cardiac hypertrophy[1].
Molecular Weight:
542.56
CAS Number:
[3061801-11-1]
Formula:
C30H27FN4O5
Target:
G Protein-coupled Receptor Kinase (GRK)
Application Notes:
MCE Product type: Reference compound
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