ADAMTS-5-IN-4 (Compound 4b) is a selective ADAMTS5 inhibitor with an IC50 of 9.4 µM. ADAMTS-5-IN-4 significantly inhibits the degradation of Aggrecan in the implants of the osteoarthritis model. ADAMTS-5-IN-4 effectively inhibits the pseudopod elongation and directional migration of ovarian cancer cells. ADAMTS-5-IN-4 shows significant cytotoxicity to HEK293T cells, human chondrocytes, and porcine chondrocyte implants. ADAMTS-5-IN-4 can be used for the study of osteoarthritis and ovarian cancer[1].
Molecular Weight:
631.74
Formula:
C30H41N5O8S
Target:
ADAMTS
Application Notes:
MCE Product type: Reference compound
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