DdBIC is a pyroptosis inducer. DdBIC binds to Nur77 and triggers its translocation to mitochondria, activates SDHA to deplete succinyl-CoA, disrupts heme homeostasis, induces electron leakage, and elicits mitochondrial ROS production. DdBIC induces mitochondrial ROS that oxidatively activates OMA1, promotes OPA1 cleavage and its release into the cytoplasm, activates the integrated stress response via PERK, and ultimately activates granzyme B to cleave GSDMC. DdBIC can be used for the study of melanoma[1].
Molecular Weight:
330.46
CAS Number:
[3085711-53-8]
Formula:
C20H30N2O2
Target:
Caspase,Nuclear Hormone Receptor 4A/NR4A,PERK,Pyroptosis,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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