LHQ766 is a highly selective, orally active, covalent FGFR2 inhibitor with an IC50 of 7.3 nM. LHQ766 significantly suppresses phosphorylation of FGFR2 and its downstream signaling molecules FRS2-a, Akt and ERK1/2. LHQ766 selectively suppresses the proliferation of FGFR2-driven cancer cells[1].
Molecular Weight:
519.54
Formula:
C28H27F2N5O3
Target:
Akt,ERK,FGFR
Application Notes:
MCE Product type: Reference compound
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