BCFTP is a potent, orally active and selective human Mas-related G protein-coupled receptor X1 (MrgprX1)-positive allosteric modulator. BCFTP selectively potentiates MrgprX1 signaling in HEK293 cells. BCFTP alleviates specific neuropathic pain-related behaviors in a humanized MrgprX1 mouse model of chronic constrictive injury (CCI) in a MrgprX1-dependent manner. BCFTP synergistically enhances psychoactive substances analgesia in CCI MrgprX1 mice. BCFTP can be used for neuropathic pain research[1].
Molecular Weight:
496.90
CAS Number:
[2781215-95-8]
Formula:
C23H17ClF4N2O2S
Target:
Mas-related G-protein-coupled Receptor (MRGPR)
Application Notes:
MCE Product type: Reference compound
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