CZL-077 is a potent, selective, and orally active p300/CBP bromodomain (BRD) inhibitor (p300 IC50 = 0.034 µM, CBP IC50 = 0.052 µM) exhibiting high selectivity over the BRDs of BET proteins (BRD2/3/4). CZL-077 inhibits cell growth with IC50 values of 0.024 µM and 5.6 µM in OPM-2 and 22RV1 cells, respectively. CZL-077 shows antitumor efficacy in OPM-2 and 22RV1 xenograft mouse models. CZL-077 can be used for multiple myeloma and prostate cancer research[1].
Molecular Weight:
577.62
CAS Number:
[3032444-06-4]
Formula:
C30H26F3N5O2S
Target:
Epigenetic Reader Domain
Application Notes:
MCE Product type: Reference compound
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