HK2-IN-3 (compound 12) is a potent hexokinase 2 (HK2) inhibitor with an IC50 of 56.4 nM. HK2-IN-3 reduces glucose uptake and downregulated GLUT1/GLUT4 in oral squamous cell carcinoma (OSCC). HK2-IN-3 induces mitophagy and apoptosis. HK2-IN-3 suppresses tumor growth and angiogenesis in OSCC xenograft mouse models. HK2-IN-3 can be used for OSCC research[1].
Molecular Weight:
329.33
CAS Number:
[2679261-30-2]
Formula:
C15H11N3O4S
Target:
Apoptosis,GLUT,Hexokinase,Mitophagy
Application Notes:
MCE Product type: Reference compound
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