MAPK-IN-6 (compound 116B) is a CNS-penetrant compound that inhibits the MAPK signaling pathway. MAPK-IN-6 reduces oxidative stress in SH-SY5Y neuronal cells by reducing ROS, restoring mitochondrial function, and inhibiting MAPK-driven inflammation. MAPK-IN-6 demonstrates profound neuroprotective efficacy in a rat tBCCAO/R model via ERK-P38-JNK signaling. MAPK-IN-6 can be used as a neuroprotective agent in ischemic stroke research[1].
Molecular Weight:
436.41
Formula:
C21H24O10
Target:
ERK,JNK,Mitochondrial Metabolism,p38 MAPK,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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