ALK/HDAC-IN-2 (Compound 19b) is an ALK/HDAC inhibitor with IC50 values for ALK WT and total HDACs of 8 nM and 1.18 µM, respectively. ALK/HDAC-IN-2 exhibits inhibitory activity against ALK mutants G1202R, F1174L, and L1196M, with IC50 values of 2.74, 9.23, and 34.28 nM, respectively. ALK/HDAC-IN-2 shows potent and selective inhibition against HDAC1 (IC50 = 0.24 µM), while its inhibitory activity against HDAC7, HDAC6, and HDAC11 is weak (IC50 > 10 µM). ALK/HDAC-IN-2 has broad-spectrum anti-proliferative activity against various cancer cells, inducing cell cycle arrest and apoptosis. ALK/HDAC-IN-2 can be used for the study of neuroblastoma[1].
Molecular Weight:
670.10
Formula:
C34H33ClN7O4P
Target:
Anaplastic lymphoma kinase (ALK),Apoptosis,HDAC
Application Notes:
MCE Product type: Reference compound
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