PAV-174 is a potent antiviral agent that targets a host protein. PAV-174 prevents Herpes simplex virus (HSV-1) infection in cells (IC50 of 0.02 µM in Vero cells) and human brain organoids. PAV-174 inhibits oxidized macrophage migration inhibitory factor (oxMIF)-induced tau phosphorylation in vitro and in vivo independent of infection. PAV-174 reduces HSV-1-induced tau phosphorylation via the Akt/GSK3beta signaling pathway. PAV-174 can be used for Alzheimers disease research[1].
Molecular Weight:
505.46
Formula:
C23H28IN3S
Target:
Akt,GSK-3,HSV,Tau Protein
Application Notes:
MCE Product type: Reference compound
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