XH-30 is a potent, selective, and orally active PKMYT1 inhibitor, with an IC50 of 4.1 nM. XH-30 suppresses the proliferation of P53-mutated triple-negative breast cancer (TNBC) cells by inducing G2/M phase release, DNA damage, and apoptosis. XH-30 demonstrates antitumor effects in an MDA-MB-231 mouse model. XH-30 can be used for P53-mutated TNBC research[1].
Molecular Weight:
337.37
CAS Number:
[3077136-87-6]
Formula:
C19H19N3O3
Target:
Apoptosis,Wee1
Application Notes:
MCE Product type: Reference compound
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