BE2012, SR8278 (HY-14415) derivative, is a potent and selective REV-ERBalpha/beta Antagonist with EC50 values of 0.285 and 0.346 µM. BE2012 binds to the ligand-binding domain (LBD) of REV-ERB, preventing the receptor from recruiting co-inhibitory factors and thereby releasing the transcriptional repression on downstream target genes. BE2012 can upregulate the expression of myogenic transcription factors Myf5 and Myod, promoting muscle regeneration and repair in acute muscle injury micemodels[1].
Molecular Weight:
293.36
CAS Number:
[667889-47-6]
Formula:
C18H19N3O
Target:
REV-ERB
Application Notes:
MCE Product type: Reference compound
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