Pro-PEG3-BA, CAS [[3057939-64-4]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-180965
Supplier Catalog Number:
HY-180965
Alternative Catalog Number:
MCE-HY-180965-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Pro-PEG3-BA is an EML4-ALK/EGFR PROTAC degrader, degrading EML4 ALK and EGFR mutant (L858R/T790M) with DC50 values of 0.42 and 13.50 µM, respectively. Pro-PEG3-BA hinders proliferation and induces cell cycle arrest and apoptosis of NSCLC cells in vitro. Pro-PEG3-BA shows safety profile and decreases EML4-ALK protein via rewiring the ubiquitin- proteasome system in vivo. Pro-PEG3-BA can be used for non-small cell lung cancer research[1][2][3].
