SIAIS056 is a BCR-ABL PROTAC degrader with a DC50 value of 0.18 nM. SIAIS056 time-dependently inhibits the BCR-ABL signaling pathway, accompanied by decreased phosphorylation of BCR-ABL and the downstream molecules STAT5 and CRKL in K562 cells. SIAIS056 induces the degradation of several clinically relevant resistance-conferring mutations of BCR-ABL. SIAIS056 exhibits anti-proliferative activity and induces substantial tumor regression in K562 xenograft models. SIAIS056 can be used for leukemia research[1][2].
Molecular Weight:
760.28
CAS Number:
[2378581-37-2]
Formula:
C35H34ClN9O5S2
Target:
Bcr-Abl,PROTACs
Application Notes:
MCE Product type: Reference compound
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