P19As is a BCR-ABL PROTAC degrader based on Asciminib (HY-104010), with a DC50 value of approximately 200 nM for the wild-type BCR-ABL protein. P19As can degrade the T315I mutant and exhibits potent anti-proliferative activity in BaF3-BCR-ABL (T315I) cells. P19As can be used for the study of chronic myeloid leukemia and acute lymphoblastic leukemia[1].
Molecular Weight:
330.38
CAS Number:
[2635386-55-7]
Formula:
C14H26N4O5
Target:
Bcr-Abl,PROTACs
Application Notes:
MCE Product type: Reference compound
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