VARS1-IN-1 is a valyl-tRNA synthetase (VARS1) inhibitor with a Kd of 0.213 µM. VARS1-IN-1 suppresses VARS1s tRNA aminoacylation activity, reduces charged levels of valine tRNAs and redues total protein synthesis rate. VARS1-IN-1 suppresses aggressive tumor growth and cell proliferation in PC3 prostate cancer xenograft models. VARS1-IN-1 can be used for the research of prostate cancer[1].
Molecular Weight:
385.44
CAS Number:
[428830-84-6]
Formula:
C21H15N5OS
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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