BMS-135 is a potenr, selective and ATP-competitive casein kinase 2 (CK2) inhibitor with IC50 of 0.8 and 0.3 nM for CK2alphaandCK2alpha' isoforms. BMS-135 can simulate the structure of ATP and bind to the active pocket of CK2, thereby inhibiting its serine/threonine phosphorylation function. BMS-135 can inhibit cells proliferation and shows anti-tumor effect. BMS-135 can be used for research of colon cancer[1].
Molecular Weight:
510.94
CAS Number:
[1541248-36-5]
Formula:
C22H23ClN10O3
Target:
Casein Kinase
Application Notes:
MCE Product type: Reference compound
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