NNRT-IN-15 (Compound 16 a) is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor. NNRT-IN-15 shows an EC50 of 3 nM for WT HIV-1 and inhibits seven mutant strains (L100I, K103N, Y181C, etc.) (EC50 = 8.2-43.4 nM). NNRT-IN-15 has low cytotoxicity against MT-4 cells (CC50 = 196.46 µM). NNRT-IN-15 also inhibit WTHIV-1RT and hERG with IC50 values of 0.7599 µM and 27.455 µM. NNRT-IN-15 can be used for research of HIV-1 infection[1].
Molecular Weight:
636.77
Formula:
C34H36N8O3S
Target:
HIV,Reverse Transcriptase
Application Notes:
MCE Product type: Reference compound
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