IK-595 is a MEK1/MEK2 inhibitor with high affinity (7.39 nM).IK-595 blocks EGF-induced ERK1/2 phosphorylation in AsPC-1 cells with IC50 value of 0.1 nM. IK-595 has oral activity and blood-brain barrier penetration. IK-595 can be used for the research of Ras/MAPK pathway-altered cancers[1].
Molecular Weight:
675.90
CAS Number:
[3018909-73-1]
Formula:
C24H24ClFIN5O5S
Target:
ERK,MEK
Application Notes:
MCE Product type: Reference compound
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