RANKL-IN-2, CAS [[2667022-87-7]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-181079
Supplier Catalog Number:
HY-181079
Alternative Catalog Number:
MCE-HY-181079-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
RANKL-IN-2 is an orally active RANKL inhibitor with Kd values of 3.21 µM and 4.625 µM in the SPR and MST assays, respectively. RANKL-IN-2 binds to RANKL to interfere with RANKL-RANK interaction. RANKL-IN-2 suppresses osteoclastogenesis by inhibiting ROS, MAPK and NF-kappaB pathways. RANKL-IN-2 inhibits osteoclastogenesis via inhibition of RANKL-induced osteoclast formation, bone resorption, and osteoclast-specific gene and protein expressions in vitro.RANKL-IN-2 prevents bone loss in ovariectomized osteoporosis mice.RANKL-IN-2 can be used for the research of osteoporosis[1].
Molecular Weight:
420.16
CAS Number:
[2667022-87-7]
Formula:
C17H13BrN2OSe
Target:
NF-kappaB,p38 MAPK,RANKL/RANK ,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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