TOP1/TDP1-IN-1, CAS [[3110679-68-7]] Preis auf Anfrage

Product Overview

• Article Name: TOP1/TDP1-IN-1, CAS [[3110679-68-7]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-181080
• Supplier Catalog Number: HY-181080
• Alternative Catalog Number: MCE-HY-181080-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

TOP1/TDP1-IN-1 is a DNA topoisomerase 1B (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitor with a TDP1 IC50 of 17.8 µM. TOP1/TDP1-IN-1directly suppresses TOP1 catalytic activity without forming a DNA-TOP1 ternary complex, inhibits TDP1-mediated repair of TOP1-induced DNA damage, and exhibits low acute toxicity. TOP1/TDP1-IN-1 disrupts DNA repair pathways, induces apoptosis, suppresses clonogenic growth, and elicits antiproliferative effects in cancer cells. TOP1/TDP1-IN-1 can be used for the research of non-small cell lung cancer, cervical cancer, colon cancer[1].

Product Properties

• Molecular Weight: 396.44
• CAS Number: [3110679-68-7]
• Formula: C22H24N2O5
• Target: Apoptosis,DNA/RNA Synthesis,Topoisomerase

Application Notes

• Application Notes: MCE Product type: Reference compound