ADAR1i-124 is an A-to-I RNA editing inhibitor by inhibiting the catalytic activities of both ADAR1p150 and ADAR1p110. ADAR1i-124 activates type I interferon (IFN) and ZBP1 pathways and dose-dependently inhibits viability across different types of cancer cell lines. ADAR1i-124 can induce cells apoptosis and necroptosis. ADAR1i-124 can be used for the research of cancer, such as cutaneous melanoma and ovarian cancer[1].
Molecular Weight:
325.75
Purity:
98.71
Formula:
C17H12ClN3O2
Target:
Apoptosis,DNA/RNA Synthesis,IFNAR,Necroptosis
Application Notes:
MCE Product type: Reference compound
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