PROTAC Tubulin degrader-2 is a cereblon (CRBN)-dependent alpha/beta-tubulin PROTAC degrader with DC50 values of 1.73 µM and 1.38 µM. PROTAC Tubulin degrader-2 can inhibit cancer cells proliferation and migration. PROTAC Tubulin degrader-2 can induce G2/M arrest, apoptosis, ROS accumulation. PROTAC Tubulin degrader-2 can be used for the research of cancer, such as non-small-cell lung cancer[1].
Molecular Weight:
755.81
Formula:
C40H45N5O10
Target:
Apoptosis,Microtubule/Tubulin,PROTACs,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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