PXS 25 is a cation-independent mannose 6-phosphate receptor (CI-M6PR) inhibitor that inhibits CI-M6PR-mediated activation of latent TGF-beta1. PXS 25 inhibits conversion of high glucose-induced latent TGF-beta1 to active TGF-beta1 in proximal tubule cells under normoxic conditions. PXS 25 suppresses high glucose-induced fibronectin, collagen IV production, and phosphorylated Smad 2 in proximal tubule cells under normoxic conditions. PXS 25 has antifibrotic properties in skin fibroblasts. PXS 25 can be used for the research of diabetic nephropathy[1].
Molecular Weight:
362.31
CAS Number:
[798546-78-8]
Formula:
C15H23O8P
Target:
TGF-beta/Smad
Application Notes:
MCE Product type: Reference compound
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