Hsp90-IN-45 is a Hsp90 inhibitor. Hsp90-IN-45 competitively binds to the ATP-binding site of purified Hsp90alpha with a Kd of 70 nM, blocks ATP hydrolysis, and disrupts Hsp90 client signaling. Hsp90-IN-45 inhibits ATPase activity of purified Hsp90alpha. Hsp90-IN-45 will be radiolabeled with 76/77Br for use as a radiotheragnostic agent for PET imaging and Meitner-Auger electron therapy. Hsp90-IN-45 can be used for the research of cancer[1].
Molecular Weight:
460.36
Formula:
C22H26BrN3O3
Target:
HSP
Application Notes:
MCE Product type: Reference compound
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