HIT211504993 is a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 0.070 µM. HIT211504993 suppresses cancer cell proliferation, cause G1 phase cell cycle arrest and induces apoptosis. HIT211504993 inhibits Myc-driven tumorigenesis via nucleocytoplasmic acetylation, p53 modulation, and Wnt/beta-catenin signaling modulation. HIT211504993 inhibits tumor growth in a colon cancer xenograft mouse model. HIT211504993 can be used for the research of colon cancer[1].
Molecular Weight:
494.99
Formula:
C23H27ClN2O6S
Target:
Apoptosis,c-Myc,HDAC,MDM-2/p53,Wnt,beta-catenin
Application Notes:
MCE Product type: Reference compound
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