IACS-56676 is a selective NRASG12D inhibitor with a target Kd of 0.031 µM. IACS-56676 stabilizes the p-loop, maintains key interactions with Asp12, Gly60 and Asp69, and achieves selectivity over wild-type KRAS through substitution targeting Leu95. IACS-56676 can be used for research on melanoma, hematologic malignancies and thyroid cancer[1].
Molecular Weight:
562.00
CAS Number:
[3105153-34-9]
Formula:
C28H28ClF4N5O
Target:
Ras
Application Notes:
MCE Product type: Reference compound
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