WRN-IN-24 is an orally active allosteric covalent Werner syndrome helicase (WRN) inhibitor with an IC50 of 201 nM. WRN-IN-24 binds to a novel allosteric cavity, forms an additional hydrogen bond with K894, and functionally inhibits WRN activity. WRN-IN-24 inhibits colorectal cancer cells proliferation and exerts dose-dependent antitumor activity in xenograft mouse models. WRN-IN-24 can be used for the research of microsatellite instability-high cancers, including colorectal cancer[1].
Molecular Weight:
603.63
CAS Number:
[3113010-46-8]
Formula:
C24H28F3N5O6S2
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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