ROCK2-IN-14, CAS [[3115784-59-0]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-181576
Supplier Catalog Number:
HY-181576
Alternative Catalog Number:
MCE-HY-181576-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
ROCK2-IN-14 is an orally active, selective ROCK2 inhibitor (IC50=4.8 nM) with 212-fold selectivity over ROCK1 (IC50=1.01 µM). By inhibiting the ROCK2/S100A9 signaling pathway, ROCK2-IN-14 downregulates S100A9 expression, inhibits NM2 phosphorylation and restores cytoskeletal abnormalities. Furthermore, ROCK2-IN-14 reduces inflammatory cytokine levels, alleviates skin inflammation and exerts anti-inflammatory activity. ROCK2-IN-14 also significantly inhibits ear thickening in a mouse model of atopic dermatitis (AD), and decreases the levels of IgE, TNF-alpha, IL-6 and TSLP. ROCK2-IN-14 has a good safety profile, with a maximum tolerated oral dose exceeding 500 mg/kg. ROCK2-IN-14 can be used for research on atopic dermatitis[1].
Molecular Weight:
434.55
CAS Number:
[3115784-59-0]
Formula:
C24H26N4O2S
Target:
ROCK
Application Notes:
MCE Product type: Reference compound
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