FP1-24 is a non-selective CK1 kinase inhibitor, with IC50 values of 40 nM, 10 nM, 10 nM, and 40 nM against human CK1gamma1, CK1gamma2, CK1gamma3 and CK1delta, respectively. FP1-24 exerts its activity by reducing the phosphorylation level of LRP5/6 at the T1479 site during WNT signaling pathway activation. The non-specific binding of FP1-24 to multiple kinases can be used for biological studies of specific CK1gamma[1].
Molecular Weight:
385.36
CAS Number:
[1403557-08-3]
Formula:
C20H17F2N3O3
Application Notes:
MCE Product type: Reference compound
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