XAN-5 is a mitochondrial DNA G-quadruplex (mtG4) ligand with a Kd of 3.8 µM. XAN-5 selectively binds and stabilizes mtG4 structures, disrupting mitochondrial gene transcription and DNA replication. XAN-5 triggers mitochondrial dysfunction, ROS overproduction, G0 phase arrest and caspase-dependent apoptosis. XAN-5 inhibits autophagy and induces immunogenic cell death. XAN-5 inhibits tumor growth in a mouse liver cancer model while enhancing tumor-infiltrating CD4+ and CD8+ T cells. XAN-5 targets two cancer resistance mechanisms simultaneously. XAN-5 can be used for the research of liver cancer[1].
Molecular Weight:
570.05
CAS Number:
[3062796-70-4]
Formula:
C29H28ClNO7S
Target:
Apoptosis,Atg8/LC3,Autophagy,Bcl-2 Family,Caspase,DNA/RNA Synthesis,Mitochondrial Metabolism,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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