MOR antagonist 2 (hydrochloride), CAS [[3075862-29-9]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-181605
Supplier Catalog Number:
HY-181605
Alternative Catalog Number:
MCE-HY-181605-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
MOR antagonist 2 hydrochloride is a blood-brain barrier-permeable µ-opioid receptor (MOR) antagonist, with an IC50 of 28.37 nM, an EC50 of 4.25 nM, and a Ki of 0.18 nM against MOR. MOR antagonist 2 hydrochloride stabilizes the inactive conformation of MOR to reduce receptor activation levels. MOR antagonist 2 hydrochloride antagonizes analgesic effects in the mouse warm-water tail-flick test. MOR antagonist 2 hydrochloride induces fewer opioid withdrawal symptoms (wet dog shakes, paw tremors) in mice with opioid withdrawal symptoms. MOR antagonist 2 hydrochloride can be used for the research of opioid use disorder[1].
Molecular Weight:
523.02
CAS Number:
[3075862-29-9]
Formula:
C28H31ClN4O4
Target:
Opioid Receptor
Application Notes:
MCE Product type: Reference compound
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