EGFR-IN-201, CAS [[3103654-99-2]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-181659
Supplier Catalog Number:
HY-181659
Alternative Catalog Number:
MCE-HY-181659-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
EGFR-IN-201 is a potent EGFR inhibitor, with an IC50 of 0.091 µM against wild-type EGFR, for mutant EGFR variants, the IC50 values of EGFRT790M, EGFRL858R and EGFRC797S are 0.147 µM, 0.221 µM and 0.703 µM, respectively. EGFR-IN-201 inhibits EGFR downstream signaling proteins AKT1 (IC50 = 0.225 µg/mL) and ERK1 (IC50 = 0.705 µg/mL). EGFR-IN-201 induces G0/G1 cell cycle arrest, apoptosis and low-level necrosis in cancer cells. EGFR-IN-201 is applicable to research on cancers such as colon cancer[1].
Molecular Weight:
340.40
CAS Number:
[3103654-99-2]
Formula:
C17H16N4O2S
Target:
Akt,Apoptosis,Bcl-2 Family,Caspase,EGFR,ERK
Application Notes:
MCE Product type: Reference compound
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